Welcome to the LFR website.
We are a research group located at the Faculty of Medicine of the University of La Laguna (Tenerife – Canary Islands) which daily work is devoted to the evaluation of renal function with a gold standard method: the clearance of iohexol.
In the last years the group developed and validated this method to measure glomerular filtration rate in clinical research and in day-to-day clinical practice, in patients in which a reliable method to evaluate renal function in necessary. More recently we simplified the method using the dried blood spot technique (DBS), which is a major step forward in order to disseminate the use of measured GFR in clinical practice. The DBS approach is simple, cheap, reduces to a minimum the blood needed for analysis and is safe. Also, we developed the clearance of iohexol in animal models, either small (mice-rats) or large (swine-sheep).
With the clearance of iohexol using DBS we have developed diverse lines of clinical and pre-clinical research in renal disease related to:
- diabetes
- obesity and metabolic syndrome
- renal and non-renal transplantation
- chronic kidney disease
- ADPKD
- living donors, among others.
LFR works in collaboration with the Hospital Universitario de Canarias (Tenerife)
In 2022, the LFR team has been awarded Project 10107907, HORIZON-WIDERA-2021, by the European Research Executive Agency. DOKI Project: Diabetes Obesity and the Kidney
National Network of Renal Function Laboratories
The National Network of Renal Function Laboratories (RN-LFR) is a group of hospitals of the National Health System, whose Biochemistry, Clinical Analysis and Nephrology Services have joined together to validate and implement a reference method to measure (not estimate) renal function: plasma clearance of iohexol, using dried blood in
paper – IOHEXOL-DBS.
Objectives of the National Network of Renal Function Laboratories: RN-LFR
The main objective of the group is to offer a simple, reliable and reproducible method to measure renal function in patients in daily clinical practice. On the other hand, the RN-LFR is proposed as a research and work group to promote clinical studies where a precise and exact measurement of the glomerular filtration rate is needed.
Participants:
Marqués de Valdecilla Hospital (Cantabria)
Jiménez Díaz Foundation (Madird)
Hospital 12 de Octubre (Madrid)
Carlos Haya Hospital (Andalusia)
Hospital del Mar (Catuña)
Vall d’Hebron Hospital (Catuña)
Bellvitge Hospital (Catuña)
Miguel Servet Hospital (Aragon)
University Hospital of the Canary Islands (Canary Islands)
University of La Laguna (Canary Islands)
Institute of Biomedical Technologies of the ULL (Canary Islands)
Funded by the Call for Personalized Medicine Projects -2022- PMP22/00119